A hybrid experimental/numerical method is proposed for predicting the junction temperature distribution in a high-power laser diode (LD) bar with multiple emitters. A commercial water-cooled LD bar with multiple emitters is used to illustrate and validate the proposed method. A unique experimental setup is developed and implemented first to measure the average junction temperatures of the LD bar emitters. After measuring the heat dissipation of the LD bar, the effective heat transfer coefficient of the cooling system is determined inversely from the numerical simulation using the measured average junction temperature and the heat dissipation. The characterized heat dissipation and effective heat transfer coefficient are used to predict the junction temperature distribution over the LD bar numerically under high operating currents. The results are presented in conjunction with the wall-plug efficiency and the center wavelength shift.